Unmeasured anions: the unknown unknowns
نویسندگان
چکیده
منابع مشابه
Unmeasured anions: the unknown unknowns
Evidence is emerging that elevated concentrations of the intermediates of the citric acid cycle may contribute to unmeasured anions in critical illness. Both the anion gap and the strong ion gap are used as scanning tools for recognition of these anions. The mechanisms underlying these elevations and their significance require further clarification.
متن کاملClosing the gap on unmeasured anions
Many critically ill and injured patients, especially those with metabolic acidosis, have abnormally high levels of unmeasured anions in their blood. At the same time, such patients are prone to hypoalbuminemia, which makes the traditional anion gap calculation inaccurate. Thus, little is known about the epidemiology and clinical consequences of an excess in unmeasured anions in the blood. Indee...
متن کاملCharting the "unknown unknowns" of cancer progression.
Integrated computational and experimental strategies reveal previously unknown regulatory programs underlying metastatic disease.
متن کاملUnmeasured anions in metabolic acidosis: unravelling the mystery
AIM To conduct a concept analysis of clinical practice contexts (work environments) that facilitate or militate against the uptake of research evidence by healthcare professionals in clinical practice. This will involve developing a clear definition of context by describing its features, domains and defining characteristics. BACKGROUND The context where clinical care is delivered influences t...
متن کاملDiscovering Unknown Unknowns of Predictive Models
Predictive models are widely used in domains ranging from judiciary and healthcare to autonomous driving. As we increasingly rely on these models for high-stakes decisions, identifying and characterizing their unexpected failures in the real world is critical. We categorize errors of a predictive model as: known unknowns and unknown unknowns [3]. Known unknowns are those data points for which t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2008
ISSN: 1364-8535
DOI: 10.1186/cc6768